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Title: Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources
Authors: Bovo, Samuele
Schiavo, Giuseppina
Ribani, Anisa
Utzeri, Valerio J.
Taurisano, Valeria
Ballan, Mohamad
Muñoz, Maria
Alves, Estefania
Araújo, José P.
Bozzi, Riccardo
Charneca, Rui
Palma, Federica Di
Kušec, Ivona Djurkin
Etherington, Graham
Fernandez, Ana I.
García, Fabián
García‑Casco, Juan
Karolyi, Danijel
Gallo, Maurizio
Martins, José Manuel
Mercat, Marie‑José
Núñez, Yolanda
Quintanilla, Raquel
Radović, Čedomir
Razmaite, Violeta
Riquet, Juliette
Savić, Radomir
Škrlep, Martin
Usai, Graziano
Zimmer, Christoph
Ovilo, Cristina
Fontanesi, Luca
Issue Date: 9-Feb-2021
Citation: Bovo, S., Silently, C., Ribani, A., Utzeri, V. J., Taurisano, V., Ballan, M., Muñoz, M., Alves, E., Araujo, J. P., Bozzi, R., Charneca, R., Palma, F. D., Kušec, I. D., Etherington, G., Fernandez, A. I., García, F., García‑Casco, J., Karolyi, D., Gallo, M., Martins, J. M., Mercat, M. J., Núñez, Y., Quintanilla, R., Radović, C., Razmaite, V., Riquet, J., Savić, R., Škrlep, M., Usai, G., Zimmer, C., Ovilo, C. & Fontanesi, L. (2011). Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources. Scientific Reports. 11:3359.
Abstract: Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identifed in the four candidate genes: 26% of them were not previously described; 29 variants afected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a frst step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described
ISSN: 2045-2322
Appears in Collections:ESA - Artigos indexados à WoS/Scopus

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