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Title: Molecular detection of metronidazole and tetracycline resistance genes in Helicobacter pylori-Like positive gastric samples from pigs
Authors: Nunes, Francisco Cortez
Taillieu, Emily
Mateus, Teresa Letra
Teixeira, Sílvia
Haesebrouck, Freddy
Amorim, Irina
Keywords: Antimicrobial resistance
Antimicrobial resistance gene
Gastric helicobacters
Sus scrofa
One Health
Issue Date: 13-May-2023
Citation: Cortez Nunes, F.; Taillieu, E.; Letra Mateus, T.; Teixeira, S.; Haesebrouck, F. & Amorim, I. (2023). Molecular Detection of Metronidazole and Tetracycline Resistance Genes in Helicobacter pylori-Like Positive Gastric Samples from Pigs. Antibiotics. 12, 906. antibiotics12050906
Abstract: Antimicrobial resistance is a major public health concern. The aim of this study was to assess the presence of antibiotic resistance genes, previously reported in Helicobacter pylori, in gastric samples of 36 pigs, in which DNA of H. pylori-like organisms had been detected. Based on PCR and sequencing analysis, two samples were positive for the 16S rRNA mutation gene, conferring tetracycline resistance, and one sample was positive for the frxA gene with a single nucleotide polymorphism, conferring metronidazole resistance. All three amplicons showed the highest homology with H. pylori-associated antibiotic resistance gene sequences. These findings indicate that acquired antimicrobial resistance may occur in H. pylori-like organisms associated with pigs.
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